The discoverers at your service!
SHODHAKA Life Sciences Pvt. Ltd.


 

 
Key areas of services offered

Data Analysis
  • Gene Expression data analysis (microarray, ESTs, RNA-seq)
  • ChIP-seq/ChIP-chip
  • NGS (Genomics, including variations such as SNPs, indels and CNVs; metagenomics)
  • Protein and other molecular interaction analysis, network visualizations
  • Gene ontology and pathway analysis
  • Mass-spec data, sequence analysis, RAPD analysis, etc.
  • Creation of custom- designed databases and Software
Biocuration

Biomarker discovery by in silico approaches

Advanced literature search

Access and analysis of molecular biology data in general

Quick links:      Illustrative Project List                     Publications                       Why us?                    Training

  1. Developing databases and performing gene expression1 analysis using microarray1 and RNA sequencing1 data [multiple projects and collaborations; 3 of the collaborative work published]
  2. Metagenomics1 analysis of sequencing data from NGS & Sanger's method in the context of human gut microbiome [completed for a medical research group in India]
  3. Reference and de novo genome sequence1 assembly, gene annotations (miRNA included), phylogenetic analysis of raw genome sequence reads [multiple projects]
  4. miRNA (microarray)1 data analysis [completed for a research group at CCMB, Hyderabad, India]
  5. Exon-array (Affymetrix)1 data analysis for brain tissue [completed for a research group at CCMB, Hyderbad, India]
  6. CHiP-seq1 data analysis [completed for a research group at KMIO, Bengaluru, India]
  7. Primer and mutation1 analysis in the context of oral cancer [completed for a company, Malaysia]
  8. Protein interaction and pathway analysis applied to mass spec and microarray data in the context of a human disease [completed for an academic research group, Mumbai, India]
  9. Development of a novel meta-analysis algorithm to make use of different types of gene expression data [in-house]
  10. Development of a new computational platform for protein-interaction analysis [in-house]
  11. Development of new RNA-protein interaction database by biocuration [in-house]
  12. Development of online test system for screening candidates for course/job-suitability in the area of life sciences [in-house]
  13. Development of a software for compiling hits obtained by literature search across multiple important resources [in-house]
  14. Development of a portal for majority of bioinformatics resources as a guide for biologists [in-house: please visit  www.startbioinfo.com for more details]
  15. Computational structural analysis to screen and dock ligands [collaboration with VIT, Tamilnadu, India; published]
1We can also carry out some of the initial wet-lab work (purifications, quality checks etc) or any other molecular biology laboratory work, in some cases, with the help of our collaborating companies.


Publications
  1. Roy D et al. Probing the Binding of Syzygium-Derived α-Glucosidase Inhibitors with N- and C-Terminal Human Maltase Glucoamylase by Docking and Molecular Dynamics Simulation. Applied biochemistry and biotechnology, [2014] 172(1):102-14
  2. Bhagwat S et al. Acetylated alpha tubulin is reduced in individuals with poor sperm motility. Fertility & Sterility,[2014] 101(1):95-104.e3
  3. Chitturi N et al. TIPMaP: a web server to establish transcript isoform profiles from reliable microarray probes. BMC Genomics, [2013] 14: 922
  4. Bhagwat SR et al. Endometrial receptivity: a revisit to functional genomics studies on human endometrium and creation of HGEx-ERdb. PLOS One, [2013] 8(3), e58419
  5. Bajpai et al. MGEx-Udb: A Mammalian Uterus Database for Expression-Based Cataloguing of Genes across Conditions, Including Endometriosis and Cervical Cancer PLOS One, [2012], 7(5), e36776
  6. Bajpai et al. In search of the right literature search engine(s) Nature Precedings, [2011]
  7. Acharya, KK et al. A novel tissue-specific meta-analysis approach for gene-expression predictions, initiated with a mammalian gene expression testis database. BMC Genomics, [2010], 11: 467
  8. Kshitish Acharya K: Capacities vs. jobs in bioinformatics and biotechnology: a few points to the attention of current students & job-seekers [2014] In: "Biotech Career Ready Reckoner 2014" (BCRR 2014), Vivify Media Private Limited & Department of Biotechnology (DBT), Govt. of India.

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